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KMID : 1149220100180010087
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Korean Journal of Oriental Medical Prescription
2010 Volume.18 No. 1 p.87 ~ p.94
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Anti-inflammatory activities of Sagunja-tang(Sijunzi-tang)
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Lee Jin-Ah
Ha Hye-Kyung
Jung Da-Young
Lee Ho-Young
Lee Nam-Hun
Lee Jun-Kyoung
Seo Chang-Seob
Kim Jung-Hoon
Lee Mee-Young
Shin Hyeun-Kyoo
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Abstract
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Objectives:To provide the information of efficacy for Sagunja-tang (Sijunzi-tang; SG), it was evaluated the anti-inflammatory effect. SG, a widely used herbal formula in tranditional Korean medicine, has been used to treat for the Boki-invigorating. In many studies, plant-derived anti-inflammatory efficacies have been investigated for their potential inhibitory effects on lipopolysaccharide (LPS)-stimulated macrophages. This study was performed to examine the anti-inflammatory effects of SG extract on LPS-stimulated RAW 264.7 cells.
Methods:The productions of nitric oxide (NO), prostaglandin (PG), interleukin (IL)-6 and tumor necrosis factor (TNF)- were examined in a macrophage cell line, RAW 264.7 cells, in the presence of the SG extract. RAW 264.7 cells were incubated with LPS and SG extract for 18 hours. The anti-inflammatory activity of SG was investigated by carrageenin-induced paw edema in rats. The paw volume was measured at 0, 2 and 4 hours following carrageenin-induced paw edema in rats.
Results:SG extract showed inhibitory effect on , IL-6 and TNF- by LPS-stimulated RAW 264.7 cells. But SG extract was not inhibitory effect on NO by LPS-stimulated RAW 264.7 cells. And administration of SG extract (1 g/kg) showed a reduction in carrageenin-induced paw edema on rats.
Conclusions:SG extract showed inhibitory effect on , IL-6 and TNF- by LPS-stimulated RAW 264.7 cells. But SG extract was not inhibitory effect on NO by LPS-stimulated RAW 264.7 cells. And administration of SG extract (1 g/kg) showed a reduction in carrageenin-induced paw edema on rats.
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KEYWORD
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Sagunja-tang(Sijunzi-tang), anti-inflammation, LPS-stimulated RAW264.7 cells, paw edema
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